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Table of Contents
January-March 2022
Volume 16 | Issue 1
Page Nos. 1-84
Online since Saturday, March 19, 2022
Accessed 14,202 times.
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EDITORIAL
Stress management
p. 1
Sanjeev Sharma
DOI
:10.4103/joa.joa_40_22
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CLINICAL STUDY: ORIGINAL ARTICLES
Evaluation of clinical efficacy and safety of “Yesaka Liquid” (an ayurvedic liquid formulation) as add-on therapy to oral hypoglycemic agents in type ii diabetes patients
p. 4
Pawankumar Godatwar, Shailesh Deshpande, Sanjay Tamoli, Shishir Pande, Amol Hartalkar, Abhay Kulkarni, Payjani Dubey, Swapnali Mahadik, Vinay Pawar
DOI
:10.4103/joa.joa_79_21
Introduction:
Yesaka Liquid is an Ayurvedic Proprietary formulation containing multiple standardized herbal extracts like Triphala (3
myrobalans
), Jamun (
Eugenia jambolana
), Kutki (
Picrorhiza kurrooa
), Haridra (
Curcuma longa
) etc., having potential anti-diabetic and anti-oxidant properties. The evaluation of clinical efficacy and safety of Yesaka Liquid as an Add-on therapy to oral hypoglycemic agents (OHAs) in Type II diabetics was the primary objective of the study.
Methods:
After obtaining ethical approval and informed consent, at five study sites, 112 patients were randomized in two study groups. The patients in Add-on Group were given Yesaka Liquid along with OHAs while those in the Control Group were asked to continue with the on-going OHA (s) for 90 days. The assessment of efficacy was done by estimation of HbA1c%, quality of life (QOL) on WHO-QOL BREF questionnaire, plasma glucose, serum insulin, symptoms of diabetes mellitus, anthropometric measurements, and changes in homeostatic model assessment for insulin resistance score. The assessment of safety was done by clinical review of all safety parameters and safety-related laboratory parameters. Global assessment of overall safety and tolerability by the physician and patient was also done.
Results:
Yesaka liquid was found to be effective as add-on therapy to OHAs in type II DM management by controlling the levels of HbA1c and blood sugar. It showed significant effect in reducing various symptoms of type II DM and also improved the QOL of patients.
Conclusion:
Yesaka Liquid can be recommended as an effective and safe formulation for the management of type II DM as an odd-on therapy.
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An open-label randomized comparative clinical study of different
Panchakarma
therapies in female infertility
p. 11
Sarvesh Kumar Singh, Archana Kushawaha, Kshipra Rajoria, Hetal Harishbhai Dave
DOI
:10.4103/joa.joa_167_21
Introduction:
Comparative role of different Ayurveda therapies in the treatment of female infertility.
Methods:
It was an open-label, comparative, randomized trial. Thirty female patients were equally divided into two groups as Group A, treated with
Virechana karma
(Purgation therapy) followed by
yoga basti
(Ayurveda enema therapy) regimen and Group B treated with
Yoga basti
followed by
Uttarabasti
(Ayurveda intrauterine therapy) regimen. In Group A,
Virechana
was done with
Tilvakaghrita
followed by
Erandmooladi yoga basti
and in Group B
Erandmooladi yoga basti
was administered followed by
Uttarabasti
with
Bala taila
. The variables used for assessments were conception, grading in menstruation parameters, spinnbarkeit (SB) test, fern test, follicular study, and endometrial thickness. For intragroup comparison, “Wilcoxon matched-paird signed-ranks test” and “paired
t
-test” were used. For intergroup comparison, “Mann–Whitney test” and “unpaired-
t
-test” were used. All the statistical tests were interpreted as significant at 5% level (
P
< 0.05).
Results:
The median age of these participants was 28 years (range, 20–36). In Group A, there were statistically significant improvements in the follicular study, SB test, menstrual parameters, and dyspareunia after the trial. In Group B, there were statistically significant improvements in endometrial thickness, Fern test, SB test, amount of menstruation, duration of menstruation, and dysmenorrhea. On comparison, there was a statistically insignificant difference between these two groups in the outcome.
Conclusion:
Ayurveda purgation-enema therapies and Ayurveda enema-intrauterine therapies are equally effective in the management of female infertility.
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Variation in different parameters of
Nadi
and pulse in accordance to
Prakriti
p. 17
Rajesh Kumar Mourya, Narendra Shanker Tripathi, Sushil Kumar Dubey
DOI
:10.4103/joa.joa_278_20
Introduction:
Nadi Pariksha
or pulse examination is one of the important tools for the examination of a healthy and in diseased person which has been recognized not only in ancient systems of medicines but also in the contemporary medicine. It has been included under
Ashtavidha Rogi Pariksha
by
Yogaratnakar
which itself signifies its importance, as it is ranked 1
st
.
Methods:
Moreover, Ayurveda scholars have many aspects of
Nadi Pariksha,
many of which are still unexplored. Thus, this exploratory study was designed and done with aim to find out any variation in parameters of
Nadi
and pulse in accordance with
Prakriti
. 200 healthy volunteers, willing to participate in the study were selected through purposive sampling method and were subjected for the assessment of
Prakriti, Nadi,
and pulse examination.
Results:
It was observed that only few parameters do vary statistically in accordance with
Prakriti
. Secondly, it was also observed that
Nadi
and
Prakriti
are showing some correlation. Irregular pulse was observed in persons having
Vata Prakriti
by using manual method. While regular pulsation was observed in the persons having
Pitta
and
Kapha Prakriti
. Mean value of pulse rate observed maximum in
Pitta Prakriti
and minimum in
Kapha Prakriti
persons by manual method.
Conclusion:
Although it was exploratory study, some relation between Nadi, Pulse and Prakriti has been observed but few of them were not found statistically significant. Second, the difference in observation through Nadi Tarangini method and manual method might have occurred due to the small sample size. Therefore, more researches may be conducted with larger sample size. It can be also said that Nadi and Prakriti are independent parameters and they are showing some correlation.
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SURVEY STUDY: ORIGINAL ARTICLES
Etiology-based survey study of skin disease as per ayurvedic text
p. 22
Bhawana Mittal, Anita Sharma, Trilok Chand
DOI
:10.4103/joa.joa_226_20
Introduction:
Our main aim is to adopt the holistic approach of Ayurveda in the prevention of disease before to treat the cause. Because of changing lifestyle and environmental conditions skin diseases are markedly increased in number.
Aims and Objectives:
To assess the effect of
Ahara
(diet) and
Vihara
(life style) on
Kushtha (
skin disease) through conceptual study and survey study is applied on clinical grounds.
Methods:
In the present study, etiological-based survey of 90 patients who visited in the outpatient department and inpatient department of the Department of
Agad Tantra
(Ayurveda Toxicology) National Institute of Ayurveda was carried out to assess the dietary and habitual lifestyles of people suffering from
Kushtha (
skin disease). The study was interview-based survey on simple randomized selection of patients. In the present study, an etiology-based survey questionnaire was prepared based on classics to assess dietary and habitual lifestyles of people suffering from skin disease.
Results:
In the present clinical study, maximum number of patients having
mandagni
.
Aam rasa
is produced due to
mandagni,
which is stated as the prime cause for almost all diseases.
Viruddahara
,
Mithyahara-vihara
are perceived as major causative factors in observation during the study.
Conclusion:
Avoidance of these aetiologies is concluded to be the first step in the direction of control and management of
Kushtha (
skin disease). As
Ahara
and its related codes and conducts have been long forgotten by the human being; therefore, this study was undertaken to evaluate and rediscover this ancient science of dietetics in Ayurveda both conceptually and clinically.
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Increased inclination towards herbal preparations as immunity booster among young adults in the times of pandemic: A cross-sectional study
p. 27
Aayushi Rastogi, Arti Nigam, Shantanu Mandal, Sunayana Nath, Rachna Kapila
DOI
:10.4103/joa.joa_7_21
Introduction:
With the lack of evidence-based specific therapy for COVID-19, the prevention against the infection and boosting the body's immunity is the only option. Experts have suggested the use of herbal plants to boost the immunity; however, the use and acceptance of herbal medicinal plants among young adults are not known. The present study is aimed at assessing the use of herbal medicinal preparations as immunity booster among young adults during the times of COVID-19 pandemic.
Methods:
A
cross-sectional study was conducted among college-going students during October 23–31, 2020. A Google form was circulated to the target group through the private and institutional networks during the study period. The questionnaire consisted of questions related to past, current, and future use of the herbal medicinal preparations. Data were extracted in MS-Excel. Univariate analysis and logistic regression was performed using the SPSS software version 21.
Results:
A
total of 318 participants with a mean age of 20.5 ± 2.1 and approximately 79% females were included in the analysis. Of the total, 65.7% participants stated some use of herbal preparations as the immunity booster during the pandemic. Type of family, monthly income of the family, and state of residence were not found to be significantly associated with the use of herbal medicinal plants during the pandemic, whereas the past use of herbal medicines, participants who considered herbal medicinal plants to be effective and safe were found to be significantly associated with the use of herbal preparations during the pandemic.
Conclusion:
A
significantly large proportion of young adults are using herbal medicinal plants as immunity booster during the pandemic indicating inclination toward traditional medicines.
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ANALYTICAL STUDY: ORIGINAL ARTICLES
An analytical study of washing pesticides on cauliflower using traditional methods
p. 34
Ambika Dhiman, Hemant Toshikhane
DOI
:10.4103/joa.joa_324_20
Introduction
: Health is the main concern for all and it is taking on serious note now a days. The potential deleterious effects of environmental chemical exposure caused serious and high concern threat to the life which indeed has gained considerable interest for research works. Cauliflower (
Brassica oleracea
var.
botrytis
L.) is one such vegetable where the maximum spraying of pesticides is in practice. There are undeniable evidences regarding the hazardous effects of the sprayed pesticides. Ayurveda has explained the purification measures for all kinds of articles which are poisoned or mixed with chemical.
Objective:
The present study was carried out to analyze the effect of washing processing on the reduction of pesticide residues in cauliflower through the gas chromatography–mass spectrophotometry (GC-MS). Residual level of pesticides in cauliflower after washing with tap water and medicated water was analyzed.
Methods:
Each cauliflower was divided into three samples and different washings were compared with the control sample.
Results:
The results of the present study showed that using medicated water, we can be able to have less contaminated cauliflower vegetable. It was concluded from this study that traditional processing methods play a significant role in the reduction of pesticides such as prefenofos and indoxicarb which are really harmful when taken fortunately and frequently with food.
Conclusion:
Medicated water sample was appreciated to been efficient method of washing is evidenced by the GC-MS. Hence, an attempt was made at such level to create the awareness about the same and follow traditional methods for washing vegetables.
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In silico
screening of identified phytochemicals from the leaf of
Cipadessa baccifera
(Roth.) miq. for its anti-psoriatic activity
p. 40
Minautee R Patel, Amit Patel, Mukeshkumar Nariya, Rabinarayan Acharya
DOI
:10.4103/joa.joa_61_21
Introduction:
Psoriasis (
kitibha
) is characterized by chronic inflammation and epidermal hyperplasia where mast cells and tryptase are activated with related form of cytokines.
Cipadessa baccifera
(Roth.) Miq. (
Meliaceae
family) is an ethnomedicinal plant reported for its anti-psoriatic tribal claim. In the present study,
in silico
docking study was planned for proven clinical use of
C. baccifera
in psoriasis with identified phytoconstituents.
Methods:
Eight identified well-known phytochemicals from the leaf of
C. baccifera
were used. The molecular docking studies were performed using iGEMDOCK2.1. Drug likeness of the compounds was predicted using Swiss ADME while
in silico
toxicity studies were performed using ProTox-II online tool.
Results:
All of retrieved eight phytoconstituents of
C. baccifera
possesses drug likeness properties. Phytoconstituents are nontoxic in nature and showing bioavailability, having significant inhibitory activities on validated anti-psoriatic targeted proteins, 2ZEB (Human Mast Cell Tryptase) and 2AOT (Histamine methyltransferase).
Conclusion:
The results of present study suggest the potential clinical role of
C. baccifera
in psoriatic patients and thus, proved the traditional claim through
in silico
docking study.
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REVIEW ARTICLES
Wholesome ayurvedic diet and lifestyle for
Sthaulya
(Obesity): A review article
p. 48
Kiran Krishniya, Bharatkumar Chhaganbhai Padhar, Ram Kishor Joshi, Sunita Rawat
DOI
:10.4103/joa.joa_71_20
Objective:
Sedentary lifestyle, unhealthy dietary habit such as excessive intake of fast foods, cold-drinks, liquors, smoking, irregularity of diet intake are the major causative factors for many lifestyle diseases such as obesity, which disturbs physical, mental as well as social health of an individual. The drugs used to treat obesity in modern medical science have several side effects and have a chance of weight gain again after the certain time limit of medication stoppage. The drug therapy is incomplete in itself, so
Pathya Ahara
(Wholesome diet) and
Pathya Vihara
(Lifestyle) need to be properly followed to manage obesity. The study aimed to review and categorize the wholesome (
Pathya
) food articles and lifestyle for
Sthaulya
(obesity) mentioned in Ayurveda Classics.
Data Source:
Ayurveda classics (mainly
Brihattrayi
Classics) were referred to review the wholesome (
Pathya
) food articles and lifestyle for
Sthaulya
(Obesity).
Review Methods:
The food articles and lifestyle mentioned in classics as
Pathya
(Wholesome) for
Sthaulya
were reviewed and organized as per various categories of food articles mentioned in Ayurveda. Results: In Ayurveda, obesity has been described as
Sthaulya
or
Medoroga
. It is described under the caption of
Santarpanottha Vikara
.
Acharya Charaka
has described the use of the
Guru
and
Atarpana
diet as a special regimen for
Sthaulya
. Various categories of diet like fruits, cereals, pulses, vegetables, sugarcane products, alcoholic and fermented food items, salt, oil, and spices, used to prepare food along with lifestyle such as proper sleep, exercise,
Yogasana
and
Pranayama
have been advised to manage the obesity.
Conclusion:
Wholesome diet from various categories of afore mentioned food articles as well as a lifestyle like proper sleep, regular exercise, and practice of Yoga can help to reduce the weight to obese persons.
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Interpretation of Charakokta Vega with Reference to Kriya Sharira
p. 55
Sangeeta Sanjay Jadhav, Hemangini Waghulade
DOI
:10.4103/joa.joa_202_20
Objective:
Ayurveda the primitive and preventative science elucidated adharneeya (nonsuppressible) Vega (natural urges) to prevent and restrain diseases.
Vega
plays a major role in the proper functioning of the body. They are regulated mainly by
Vata
with the support of other subtype of dosha and the controlled and guided activities of mind.
Vega Dharana
is considered as the contributory cause of many chronic diseases and acute physiological conditions.
Data Source:
Classical Ayurvedic texts along Charka are searched to interpret the Ayurvedic physiology of each
Vega
.
Review Methods:
Both Ayurveda and modern recent researches on natural
Vega
, and their therapeutic significance is explored through electronic search.
Result:
Understanding the physiology of
Adharneeya Vega
is crucial for the etiopathogenesis of their consequences and other related diseases described by Ayurveda classics.
Conclusion:
In the present article, an attempt has been made to explore the concept of
adharaneeya Vega
mentioned in
Charaka samhita
with contemporary relevance in clinical Ayurveda practice and thereby aid in health promotion and also as a preventive tool.
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“An analytic assortment of diet and dalliance in
Srotodushti
with special reference to
Jwara
” A review study
p. 60
Shalinee Kumari Mishra, Vd. Kamalesh Kumar Sharma, Dharmendra Mishra
DOI
:10.4103/joa.joa_203_20
Objectives:
To identify and explore the
Apathya
and
Pathya
according to the
Srotasa
in
Jwara
.
Data Source:
Charak Samhita Vimana Sthana
and
Charaka Samhita Chikitsa Sthana
, available all
Sanskrit commentaries
on
Charak Samhita
, and other commentary on
Astanga Sangrah
and
Astanga Hridaya Samhita
.
Review Methods:
Profound explorative review study of all collected material using offline and online available texts.
Result and Con
clusion:
One year old Cereals and pulses, husked grains
Mudga (Phaseolus aureus), Jeevanti, Solanum nigram, (Kakamachi), Corchorus capsularis, Centella asiatica (Brahmi), (Mandukaparni), Trichosanthes dioica (Patola)
are some vegetable and dietary substance to be used.
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Hemadri - Renowned Commentator of
Ayurvedarasayana
Commentary on
Ashtangahridayam
p. 65
Vishwavasu Gaur, Vaidya Banwari Lal Gaur
DOI
:10.4103/joa.joa_277_21
Background:
Hemadri, the prominent minister of King Mahadeva and Ramdeva of Devagiri, Maharashtra, was very eminent scholar belonging to the 13
th
–14
th
century. He has written many scholarly books and
Ayurvedarasayana
commentary on
Ashtangahridayam
is considered his masterpiece.
Objective:
The objective of this study is to enlighten the contribution of Acharya Hemadri in the field of Ayurveda.
Data Source:
The books, i.e.,
Ayurvedarasayana
commentary on
Ashtangahridayam,
Life of Hemadri,
Vagbhatavimarshah, KashyapasamhitaUpodghata,
etc., have been reviewed.
Review Methods:
Thorough study of data source followed by critical and rational analysis of the life and works of Hemadri.
Results and Conclusion:
The commentary is incomplete, but it is written with a practical approach and the author has amended the order of chapters and has organized it more systematically. The remarkable features of his commentary are the reorganization of
Nidanasthana
and
Chikitsitasthana
in such a way that after each chapter of
Nidanasthana
the corresponding
Chikitsita
is explained.
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CASE REPORTS
Efficacy of trinapanchamoolkwath in the management of urinary tract infection during pregnancy (
Mutrakruccha in Garbhini
) - A case study
p. 71
Preeti Chouhan, Ayush Kumar Garg
DOI
:10.4103/joa.joa_211_20
Introduction:
Urinary tract infection during pregnancy and postpartum is a common obstetric complication. The term
Mutrakruchha
comes under the disorders of
MutravahaSrotas
, and mainly deals with
shool
(pain) and
krucchrata
(dysuria). This article discusses a female patient with a history of 6 months 24 days of pregnancy seen in the OPD of Prasuti Tantra, Sir SundarlalHospital, IMS, BHU.
Main Clinical Finding:
Her chief complaints were painful, difficult urination with burning along with pain in the suprapubic region for 8 days.
Diagnosis:
In this case, the patient has an urge to micturate, but she passes urine with pain. The painful voiding of urine is diagnosed as
Mutrakruchha
.
Interventions:
After appropriate analysis based on ayurvedic and modern parameters, the patient was treated with
Trinapanchmulakwath
.
Outcome:
Before treatment, her scoring of subjective parameters was 13 and after treatment, her score decreased to 2. Thus, the treatment module showed significant relief in the symptoms by 84.62%. Laboratory investigation showed marked improvement as pus cells were reduced to 0–1/high power field (HPF) from 10 to 12/HPF and epithelial cells were reduced to 1–2/HPF from 9 to 10/HPF.
Conclusions:
All the symptoms and investigations showed highly significant results, hence it can be concluded that this medicine is very effective in patients of
garbhinimutrakruchha.
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Role of ayurveda in antimicrobial resistant pharyngitis
p. 76
Anshul , Pooja Rohilla, Ashish Mehta
DOI
:10.4103/joa.joa_98_21
Introduction:
Purpose of the study is to manage recurrent pharyngitis (
Ekvrindamukharoga
) because antibiotic resistance issue is a big concern as there is no permanent management in conventional medicine.
Main Clinical Finding & Diagnosis:
The present case was diagnosed with viral pharyngitis on basis of fever, sore throat &lymphocytosis.
Interventions:
TalishadiChurna, Mrityunjaya rasa, Laxmivilasa rasa & Tankana
were administered for 3 days and subsequently
Vamana
(~induced therapeutic vomiting) was performed to prevent recurrence. Outcome: Major improvement recorded in oral temperature, color (beefy red to light pink), etc., after the intervention. Throat pain (from 5 point to 1) and swelling (from 2 to 1) after 2 h and were relieved completely after 3 days.
Conclusion:
This case study reports effective management of antimicrobial-resistant acute pharyngitis with stand-alone Ayurvedic therapy. Non-relapse of symptoms after
Vamana
during the follow-up period (6 months) emphasizes the effective secondary prevention achieved with Ayurveda.
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A progressive revival of semivegetative patient of head injury with ayurvedic treatment
p. 80
Yogesh Chandrakant Kale, Yashashree V Joshi, Barakha V Kulkarni
DOI
:10.4103/joa.joa_154_21
Introduction:
The presented case report depicts gradual revival of a patient with head trauma from semivegetative state with complete Ayurvedic treatment.
Main Clinical Findings:
The patient was in semivegetative state with least mobility, due to partial motor function loss, drowsiness, speech and memory loss, no sensation or control over micturition and defecation, and need of PEG tube for feeding.
Diagnosis:
Shirobhighatajanya Vatavyadhi
and
Sannyasa.
Interventions:
Complete Ayurvedic treatment was administered focusing on
Vatashamana, Raktaprasadana, Agnideepana, Marmaparipalana,
and
Indriyaprabodhana.
Outcome:
Mobility, speech and memory improvement, oral solid food intake by herself, and proper sensation and control over micturition and defecation are the main satisfactory outcomes.
Conclusions:
Timely and complete Ayurvedic diagnosis and Ayurvedic treatment along with
Chatushpada Sampatchikitsalaya
are the key factors in treating chronic and critical conditions of
Marmabhighata.
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